Platelet-Lysate-Expanded Mesenchymal Stromal Cells for the Treatment of Resistant GVHD
نویسندگان
چکیده
منابع مشابه
MESENCHYMAL STROMAL CELLS IMPLANTATION IN COMBINATION WITH PLATELET LYSATE PRODUCT IS SAFE FOR RECONSTRUCTION OF HUMAN LONG BONE NONUNION
This was Presented in 5th International Congress of Iranian Iranian Society of Knee Surgery, Arthroscopy, and Sports Traumatology (ISKAST), 14-17 Feb 2018- Kish, Iran
متن کاملTreatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC).
BACKGROUND Several studies revealed that MSC from human bone marrow can downregulate graft-versus-host disease (GVHD) after allogeneic HSCT. METHODS Herein we present 50 patients with acute GVHD who got 74 (1-4) MSC infusions for 54 separate episodes of aGVHD. RESULTS aGVHD was defined as steroid resistant grade IV aGVHD in 42 cases. The major presentation was gastrointestinal GVHD; two (n=...
متن کاملmesenchymal stromal cells implantation in combination with platelet lysate product is safe for reconstruction of human long bone non:union:
objective: non:union: is defined as a minimum of 9 months since injury without any visible progressive signs of healing for 3 months. recent literature has shown that the application of mesenchymal stromal cells is safe, in vitro and in vivo, for treating long bone non:union:. the present study was performed to investigate the safety of mesenchymal stromal cell (msc) implantation in combination...
متن کاملAdipocyte Derived Mesenchymal Stromal Cell and Platelet Lysate: Ideal Cell and Supplement for the Treatment of Immune-Inflammatory Diseases?
Background: Mesenchymal stromal cells (MSC) are being tested for the treatment of immune diseases. MSC are present in several adult tissues which milieu may influence MSC behavior particularly under inflammatory conditions. Additionally, culture conditions also can modify cell function or state of activation. Methods: To address the influence of the MSC source on its characteristics, we studied...
متن کاملhuman platelet lysate as a xeno free alternative of fetal bovine serum for the in vitro expansion of human mesenchymal stromal cells
background: mesenchymal stromal cells (mscs) are employed in various different clinical settings in order to modulate immune response. human autologous and allogeneic supplements including platelet derivatives such as platelet lysate (pl), platelet-released factors (prf) and serum are assessed in clinical studies to replace fetal bovine serum (fbs). the immunosuppressive activity and multi-pote...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2011
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2010.12.054